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09-Sep-2020 03:48

Particular anaesthetic problems in patients with Parkinson’s disease are respiratory, cardiovascular, and neurological.

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In Parkinson’s disease, there is a 30–40% decrease in complex‐1 activity in the substantia nigra pars compacta which may contribute to energy failure and hence predispose the pars compacta to toxic insults and increase its susceptibility to cell death.68 Oxidative stress may be caused by an increase in the number of reactive species including hydrogen ions, superoxide, peroxyl radicals, nitric oxide, and hydroxyl radicals.Parkinson’s disease is an increasingly common disease of elderly patients who present a particular anaesthetic challenge.