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The IG analysis confirms the role of some of the histone marks, like H3K9ac and H3K27ac, in the promoter andaround the transcription start site in expression regulation as described before in the literature; and uncovers new regions, like the first intron for H3K36me3, the first exon for H3K4me3 and downstream ofthe polyadenylation site for H3K36me3, where changes in these marks associate strongly with expression regulation. After having shown a high accuracy of expression change predictions between the cell lines K562 and Gm12878 (training set), we could prove that the model trained on this data was generic enough to perform accurate predictions on Hsmm and Hmec (testset), a different pair of cell lines.… continue reading »
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